# Best Python autonomous agents

> The open-source autonomous agents written in Python, from the Agent Search Engine index — ranked by real maintained adoption (GitHub stars and recent commit activity), never by sponsorship. Every project here is Python-first, self-hostable, and free to run; the trade-off is you host and maintain it yourself.

Right now it's led by AutoGPT (186k stars), with browser-use and deer-flow close behind. Rankings shift as projects gain stars and ship commits.

9 open-source records, ranked by maintained GitHub adoption; sponsorship never affects the ranking. Browse on the web: https://agentsearchengine.app/best/python-autonomous-agents

## Ranked

1. [AutoGPT](https://agentsearchengine.app/agents/autogpt) — AutoGPT is the vision of accessible AI for everyone, to use and to build on. Our mission is to provide the tools, so that you can focus on what matters. · Open source · Agent · 186k★ · Python · active today · best for experimenting with long-running autonomous agent loops in an open-source stack
2. [browser-use](https://agentsearchengine.app/agents/browser-use) — Make websites accessible for AI agents. Automate tasks online with ease. · Open source · Agent · 108k★ · Python · MIT · active today · best for developers giving agents real browser control via an open-source python library
3. [deer-flow](https://agentsearchengine.app/agents/deer-flow) — An open-source long-horizon SuperAgent harness that researches, codes, and creates. · Open source · Agent · 79k★ · Python · MIT · active today · best for orchestrating sub-agents, memory, and sandboxes through one extensible skill system
4. [nanobot](https://agentsearchengine.app/agents/nanobot) — Lightweight, open-source AI agent for your tools, chats, and workflows. · Open source · Agent · 47k★ · Python · MIT · active today · best for a small, readable self-hosted agent framework with memory and mcp built in
5. [CowAgent](https://agentsearchengine.app/agents/cowagent) — Open-source super AI assistant & Agent Harness. Plans tasks, runs tools and skills, self-evolves with memory and knowledge. Multi-model, multi-channel. Lightweight, extensible, one-line install. · Open source · Agent · 46k★ · Python · MIT · active today · best for an always-on personal assistant that controls your computer and chat platforms
6. [agno](https://agentsearchengine.app/agents/agno) — Build, run, and manage agent platforms. · Open source · Agent · 42k★ · Python · Apache-2.0 · active today · best for running a self-owned agent platform with rbac, a runtime, and a management ui
7. [wshobson/agents](https://agentsearchengine.app/agents/wshobson-agents) — Multi-harness agentic plugin marketplace for Claude Code, Codex CLI, Cursor, OpenCode, GitHub Copilot, and Gemini CLI · Open source · Platform · 38k★ · Python · MIT · active 12 days ago · best for a prebuilt library of agents and skills shared across claude code, cursor, and codex
8. [agenticSeek](https://agentsearchengine.app/agents/agenticseek) — Fully Local Manus AI. No APIs, No $200 monthly bills. Enjoy an autonomous agent that thinks, browses the web, and code for the sole cost of electricity. · Open source · Agent · 27k★ · Python · GPL-3.0 · active 2 days ago · best for a fully local manus alternative that keeps browsing and coding on your own hardware
9. [agentic_security](https://agentsearchengine.app/agents/agentic-security) — Agentic LLM Vulnerability Scanner / AI red teaming kit · Open source · Agent · 1.9k★ · Python · Apache-2.0 · active 3 days ago

## FAQ

**What are the best Python autonomous agents?**
The Python projects listed below, ranked by maintained adoption — GitHub stars plus recent commit activity — so you see what's genuinely used and still maintained, not abandoned.

**Are these Python autonomous agents open source and free?**
Yes — every project on this page is open source and written primarily in Python. The software is free to run and self-host; you still pay for the infrastructure you run it on and any model or API usage it makes.

**Why choose Python autonomous agents specifically?**
Staying in your team's primary language — Python — makes self-hosting, extending, and debugging far easier, because you can read and modify the source directly instead of treating it as a black box.

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Source: [Agent Search Engine](https://agentsearchengine.app) — https://agentsearchengine.app/best/python-autonomous-agents